show Abstracthide Abstract1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxin that can cause gastrointestinal ulcers by affecting dopamine levels. Therefore, MPTP has been considered a toxic substance that causes gastric ulcer disease in experimental animals. In this study, Tupaia belangeri were used as the animal model of gastric mucosa injury, and MPTP was intraperitoneally injected at a lower MPTP dosage 2mg/kg/day for 13 weeks, while Tupaia belangeri were not injected as the control group. In order to explore the molecular basis of changes in MPTP induced gastric mucosa injury, the transcriptome data of gastric mucosa were analyzed.